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KMID : 0376419880120040355
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Chonbuk University Medical Journal
1988 Volume.12 No. 4 p.355 ~ p.361
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Studies on the Contractile Action of 5-Hydroxytryptamine in the Isolated Rabbit Intestine
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Hwang Ho-Yong
Han Kyu-Song
Kwak Yong-Geun
Cho Kyu-Park
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Abstract
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To investigate the mechanism of contractile action of 5-hydroxytryptamine(5-HT) on the isolated intestinal smooth muscle preparation of rabbit, the influence of cyproheptadine, atropine, hexamethonium, morphine and hem icholinium treatment on the action of 5-HT were studied´ in this experiment.
Results obtained from this experiment were summerized as follows
1. 5-HT caused contractile response of isolated intestinal smooth muscle in dose-dependent manner.
2 . In the intestinal preparation of saline treated rabbit, contractile action of 5-HT was inhibited by cyproheptadine, atropine or morphine, but not influenced by hexamethonium.
3 . In the hemicholinium-pretreated preparations, the contractile response of intestinal smooth muscle was significantly inhibited by cyproheptadine, but did not inhibited by atropine or morphine. And also, hexamethonium did not influenced on the action of 5-HT as in the preparation of saline-treated rabbit.
These results suggest that there are two mechanisms responsible for contractile action of 5-HT in the isolated rabbit intestinal smooth muscle preparation. One is the 5-HT receptor on the smooth muscle(possibly D receptor), and the other is the receptor on the parasympathetic ganglia which different from the hexamethonium-sensitive sites.
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KEYWORD
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5-Hydroxytryptamine, contractile action, isolated rabbit inteetine
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